β1 integrin maintains integrity of the embryonic neocortical stem cell nicheβ1整合素保持完整的胚胎神经干细胞利基.pdf

b1 Integrin Maintains Integrity of the Embryonic Neocortical Stem Cell Niche 1. 2,3,4,5. 2,3 6 5 Karine Loulier , Justin D. Lathia , Veronique Marthiens , Jenne Relucio , Mohamed R. Mughal , Sung- 5 7 2,3,4 5 8 6 Chun Tang , Turhan Coksaygan , Peter E. Hall , Srinivasulu Chigurupati , Bruce Patton , Holly Colognato , Mahendra S. Rao9,10, Mark P. Mattson5,10, Tarik F. Haydar1.*, Charles ffrench-Constant2,3,4¤.* 1 Center for Neuroscience, Children’s National Medical Center, Washington, D.C., United States of America, 2 Department of Pathology, University of Cambridge, Cambridge, United Kingdom, 3 Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom, 4 Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom, 5 Laboratory of Neuroscience, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America, 6 Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York, United States of America, 7 School of Medicine, University of Maryland, Baltimore, Maryland, United States of America, 8 Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon, United States of America, 9 Corporate Research Laboratories, Invitrogen Corporation, Carlsbad, California, United States of America, 10 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Abstract During embryogenesis, the neural stem cells