the chemokine receptor cxcr4 strongly promotes neuroblastoma primary tumour and metastatic growth, but not invasion趋化因子受体cxcr4强烈促进神经母细胞瘤原发肿瘤和转移性增长,但不是入侵.pdf

The Chemokine Receptor CXCR4 Strongly Promotes Neuroblastoma Primary Tumour and Metastatic Growth, but not Invasion 1 ¨ 1 1 ´ 1 2 3 1 Roland Meier , Annick Muhlethaler-Mottet , Marjorie Flahaut , Aurelie Coulon , Carlo Fusco , Fawzia Louache , Katya Auderset , Katia Balmas 1 4 5 4 1. 6. Bourloud , Estelle Daudigeos , Curzio Ruegg , Gilles Vassal , Nicole Gross *, Jean-Marc Joseph 1 Department of Paediatrics, Paediatric Oncology Research, University Hospital Centre Hospitalier Universitaire Vaudois Lausanne (CHUV), Lausanne, Switzerland, 2 Division of Experimental Pathology, University Institute of Pathology, Lausanne, Switzerland, 3 INSERM U362, Institut Gustave Roussy, ´ ´ Villejuif, France, 4 Unite Propre de Recherche de l’Enseignement Superieur EA3535, Institut Gustave Roussy, Villejuif, France, 5 Division of Experimental Oncology, Multidisciplinary Oncology Centre (CePO), Lausanne Cancer Centre, Lausanne, Switzerland, 6 Department of Paediatrics, University Hospital Centre Hospitalier Universitaire Vaudois Lausanne (CHUV) Surgery Unit, Lausanne, Switzerland Neuroblastoma (NB) is a heterogeneous, and particularly malignant childhood neoplasm in its higher stages, with a propensity to form metastasis in selected organs, in particular liver and bone marrow, and for which there is still no efficient treatment available beyond surgery. Recent evidence indicates that the CXCR4/CXCL12 chemokine/receptor axis may be involved in promoting NB invasion and metastasis. In this study, we explored the potential role of CXCR4 in the malignant behaviour of NB, using a combination of in vitro