cerbB2p53PCNA_ER_PR及Topo_在乳腺癌的表达及其临床.pdf

蚌埠医学院学报 2006年 9月第 31卷第 5期 447 [ ] 1000-2200 ( 2006) 05-0447-04 基础医学 c-erbB-2p53PCNAERPRTopo 1 2 , [ ] 目的 c- erbB-2p5 3 ( proliferating ce ll nu c lear antigen, PCNA ) DNA ( DNA topo isom erase , T opo ) ( estrogen receptor, ER ) ( progesterone receptor, PR ) 方法 89 EnV ision 结果 c- erbB-2p5 3T opo PCNA 64. 04% 29. 21% 55. 0 6% 59. 55% , c- erbB-2PCNA ( P 0. 05) , PCNA T opo( P 0. 05 ) 结论 c-erbB-2 PCNA , T opo [ ] ; c-erbB-2; p5 3; ; DNA ; ; [ ] R 737. 9 [ ] A Expression of c-erbB-2, p53, PCNA, ER, PR andTopo in breastcancerand its clinical significances 1 2 ZHANG Q iong , ZHU Y u-zh ao ( 1. D ep artm ent of P atho logy, B engbu M edical College, B engbu 233030; 2. D epartm ent of Pathology, ChanghaiH osp ital, Second M illitary M edical Uni ersity, Shanghai 200433, China ) [Abstract] bjective: To eva lu ate the c lin icop atho log ical sign if icance of expression s o f c- erbB-2, p53, pro lifera ting ce ll nu clear antig en ( PCNA ) , DNA topo isom erase ( Topo) , estrogen recep to r( ER ) and prog este rone recepto r( PR ) in breast cancer. M ethods: E ighty-nine cases of p araff in-embedded spec mi en s of breast carc inom a w ere stu died by mi munoh istochem ical techniqu e. Results: T he positive ra tes of c- erbB-2, p5 3, T opoand PCNA w e re 64. 04% , 29. 2 1% , 55. 0 6% , and 59. 55% , respectively. The expression s of c- erbB-2, PCNA w ere positiv ely co rre lated w ith lym ph node m e tastases( P 0. 05) , and the re w as the c losely relation sh ip betw een PCNA and invasive m amm ary ca rc