复方参归汤对拟阿尔茨海默病小鼠学习记忆的改善作用.pdf

626 20 11 2 31 曾雪爱 黄俊山 陈道亮 周春权 林求诚 (福建省中医药研究院, 福建 福州 350003) (A D) , D- AD , , (A chE ) AD (P 005) , A chE (P 005) , D- , ; ; ; R2855 A 1005-9202( 2011 ) 04-0626-02 Im proving effect of compound Rad ix Sa viae m i tiorrh izae-Rad ix A nge icae sin en sis decoc tion on earn ing and m em ory cap ab i ity in poten tia A zhe im ers d isease m ice and its possib e m echan ism ZENG Xue-A i, HUANG Jun-Shan, CHEN D ao-L iang, et a l Fujian Institu te of T radition a Ch ineseM ed ic ine, Fuzhou 350003, Fujian, Ch ina Ab stract O bjective T o study the e ffect o f the com pound R adix Sa v iae m i tio rrhizae-R adix A ng e icae sinens is deco ction ( SA ) on m ice induced for A zhe mi ers disease ( AD ) and its possib e m echan ism M ethod s D-ga actose and sodium nitrite w ere g iv en ip to young m ice once da iy for 11w eeks to induce A D, m eanw hi e SA a t 10 and 20 g / kg w as gavaged to prevent AD in trea tm en t group s 1 w eek at- e rA fte r treatm ent w ith SA for 10 w eeks, the earn ing and memo ry capabi ity and the serum acety cho ine esterase ( A chE ) activ ity of the m ice w ere m easuredR esu ts SA at 10 g / kg mi proved the ea rning and m em ory capab i ity of AD- induction m ice ( P 005, P 001 o r P 0001) T he se rum A chE activ ity w as increased in A D- induction m ice (P 005) SA at 10 and 20 g / kg reduced the increased A chE activ ity (P 005) Con c usions SA can sign ificant y mi prove the ea rn ing and m emo ry capabi ity in the potentia AD m ice, the under y- ing m echan ism m ay be re a ted to the inhibition of serum A ChE activ ity K ey words A zhemi ers disease; N ove com pound herba m ed icine; L ea rning and M em o ry; A ce ty cho inesterase , ( AD ) ) ; ( A chE ) ( 1 ) ,