LMP1在鼻咽癌中的研究HeadandNeckOncology2012aboutLMP1inNPC.pdf

Page 1 of 7 Original research study Prognostic signifi cance of pre-treatment latent membrane protein 1 from nasopharyngeal swabs for stage III–IVA nasopharyngeal carcinoma 1,2† 2† 1 3 3 1 1 1,4 1 2 Q Guo , IWK Tham , S Lin , Y Su , Z Chen , J Lin , L Han , Q Lin, MD , J Pan *, JJ Lu * Abstract Results in particular, to improve distant Background Of the 87 swab samples, LMP1 was metastasis-free survival rates. Besides Previous studies have proposed that detected in 75 (86.2%). Overall sur- advanced clinical stage, there is cur- the latent membrane protein 1 (LMP1) vival rates were significantly higher rently no reliable prognostic marker gene is related to the pathogenesis in patients without LMP1 expression to select patients at higher risk of (LMP1−) compared with those with distant metastases prior to onset of . and progression of nasopharyngeal t p LMP1 (LMP1+) (100% vs. 71.6%, re- treatment. i carcinoma. However, th