CMU高级机器学习隐马尔可夫模型与条件随机场.pdf

Advanced Machine Learning Advanced Machine Learning Structured Models: Structured Models: Hidden Markov Models versus Hidden Markov Models versus Conditional Random Fields Conditional Random Fields Eric Xing Eric Xing Lecture 9, August 12, 2009 Reading: Eric Xing © Eric Xing @ CMU, 2006-2009 1 Dynamic clustering Eric Xing © Eric Xing @ CMU, 2006-2009 2 1 Clustering Tumor Cell States Chromosomes of tumor cell: Eric Xing © Eric Xing @ CMU, 2006-2009 3 Array CGH (comparative genomic hybridization) The basic assumption of a CGH experiment is that the ratio of the binding of test and control DNA is proportional to the ratio of the copy numbers of sequences in the two samples. But various kinds of noises make the true observations less easy to interpret … Eric Xing © Eric Xing @ CMU, 2006-2009 4 2 DNA Copy number aberration types in breast cancer