G蛋白偶联受体激酶.pdf

·1438 · 中国病理生理杂志 Chinese Journal of Pathophysiology 2011，27 (7):1438 － 1444 ［ ］ 1000 － 47 18 (2011)07 － 1438 － 07 文章编号 G 蛋白偶联受体激酶在细胞迁移和 细胞信号转导中的作用* 1 2 2 2 △ ， ， ， 蔡 欣 陈 京 张敬美 白 波 1 2 ( ， 27 1000 ; ， 272000) 泰山医学院 山东泰安 济宁医学院 山东济宁 Role of G － protein － coupled receptor kinases in cell migration and signal transduction 1 2 2 2 CAI Xin ，CHEN Jing ，ZHANG Jing － mei ，BAI Bo 1 2 (Taishan Medical University ，Tai ’an 27 1000 ，China ;Jining Medical University ，Jining 272000 ，China． E － mail :bbai @ mail． j nmc． edu． cn) ［ABSTRACT］ G － protein － coupled receptor kinases (GRKs)are a family of serine / threonine protein kinases． The investigators pay much attention to the roles of GRKs in the signal transduction through G － protein － coupled receptors (GPCRs)with arrestin ever since a long time ago． Due to the physiological and pathological observations with the methods of deletion or overexpression ，GRKs are considered as new drug targets． The kinases play a role in the pathogenesis of hy- pertension and cell migration through GPCRs and Hedgehog signaling pathways． As the development of research tech- niques ，especially bioluminescence resonance energy transfer (BRET )and fluorescence resonance energy transfer (FRET)，the special mechanism of GRKs for GPCRs is more evident． In this review ，we discuss the recent achievement in the roles of GRKs signaling and the related newest