噬菌体治疗——旧概念,新阶段.PDF

微生物学通报 NOV 20, 2011, 38(11): 1698−1704 Microbiology China © 2011 by Institute of Microbiology, CAS tongbao@ 专论与综述 噬菌体治疗——旧概念, 新阶段 赵晨 王辂* (抗生素研究与再评价四川省重点实验室 中国医药集团总公司四川抗菌素工业研究所 四川 成都 610052) 摘 要: 噬菌体治疗技术由来已久。噬菌体治疗的研究始于上世纪初, 之后由于抗生素的出现及 其他原因在美国和西欧等国家中断。近年来, 全球范围的细菌耐药性使得科学家们重新审视和评 估噬菌体治疗技术, 显示出巨大潜力。论述噬菌体发现历程及早期研究、人类及动物细菌感染的 应用、噬菌体治疗与抗生素的不同之处、存在的问题等, 并探讨噬菌体技术可能的发展应用方向。 关键词: 噬菌体, 噬菌体治疗, 细菌感染, 抗性 Bacteriophage therapy, old idea, new stage ZHAO Chen WANG Lu* (Antibiotic Research and Re-profiling Key Laboratory of Sichuan Province , Sichuan Industrial Institute of Antibiotics China National Pharmaceutical Group Corporation, Chengdu, Sichuan 610052, China) Abstract: Bacteriophage therapy had been considered as an effective way for bacterial infection treat- ment for a long time. The research was started in the beginning of twenty century, but discontinued in America and Western Europe with the advent of antibiotics. Recently, scientists started to re-evaluate the bacteriophage therapy due to the worldwide bacteria resistance and found the great potential of phage-based prophylaxis and therapy of antibiotic-resistant bacterial infections. This paper reviews the history of bacteriophage therapy and the application in the treatment of human and animal bacterial in- fection, compares the difference between bacteriophage and antibiotics therapy and also discusses the existing problems and the future development of this technique. Keywords: Bacteriophage, Bacteriophage th