the goat-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restrictiongoat-ghrelin系统不是必要的预防低血糖期间长期热量限制.pdf

The GOAT-Ghrelin System Is Not Essential for Hypoglycemia Prevention during Prolonged Calorie Restriction 1 2 2 2 3 Chun-Xia Yi , Kristy M. Heppner , Henriette Kirchner , Jenny Tong , Maximillian Bielohuby , Bruce D. 4 ¨ 1 2 2 2 2 Gaylinn , Timo D. Muller , Erin Bartley , Harold W. Davis , Yongmei Zhao , Anupama Joseph , Traci 2 2 1 2 2 Kruthaupt , Nickki Ottaway , Dhiraj Kabra , Kirk M. Habegger , Stephen C. Benoit , Martin 3 4 2 ¨ 1 1 Bidlingmaier , Michael O. Thorner , Diego Perez-Tilve , Matthias H. Tschop , Paul T. Pfluger * 1 Institute for Diabetes and Obesity, Helmholtz Centre Munich, Neuherberg, Germany, 2 Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio, United States of America, 3 Endocrine Research Unit, Medizinische Klinik - Innenstadt, Ludwig-Maximilians University, Munich, Germany, 4 Department of Medicine, Division of Endocrinology, University of Virginia, Charlottesville, Virginia, United States of America Abstract Objective: Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of- function models for the GOAT/ghrelin/growth hormone secretagogue receptor (GHSR) system, we thoroughly tested the hypothesis that lack-of-ghrelin activation or signaling would lead to hy