the differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation肿瘤坏死因子的差贡献在慢性炎症热力和机械痛觉过敏.pdf

Available online /content/7/4/R807 Vol 7 No 4 Open Access Research article The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation 1 1 2 3 1 Julia J Inglis , Ahuva Nissim , Delphine M Lees , Stephen P Hunt , Yuti Chernajovsky and Bruce L Kidd1 1Bone and Joint Research Unit, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, London, UK 2Experimental Therapeutics, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, London, UK 3Department of Anatomy and Developmental Biology, University College London, London, UK Corresponding author: Bruce L Kidd, b.l.kidd@qmul.ac.uk Received: 5 Oct 2004 Revisions requested: 3 Dec 2004 Revisions received: 21 Feb 2005 Accepted: 16 Mar 2005 Published: 12 Apr 2005 Arthritis Research Therapy 2005, 7:R807-R816 (DOI 10.1186/ar1743) This article is online at: /content/7/4/R807 © 2005 Inglis et al.; licensee BioMed Central Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Therapies directed against tumour necrosis factor (TNF) are expression on DRG cells, which was maintained throughout the effective for the treatment of rheumatoid arthritis and reduce time course of the model. TNFR1 expression was increased in pain scores in this condition. In this study, we sought to explore neuronal cells of the DRG