肝再生相关细胞因子探究_吕璟.pdf

解剖科学进展　Progress ofAnatom icalSciences　2005, 11(2):174 ～179 肝再生相关细胞因子的探究 吕　 (首都医科大学细胞生物学系 2002级硕士研究生, 北京 100054) 【 要】　肝脏再生是一个极其复杂、多因素参与的过程, 而其中的细胞因子起着至关重要的作用。这些 因子主要包括:起始因子或者前炎性因子如肿瘤坏死因子 (TNF-α)、白细胞介素 6(IL-6)等;肝细胞生长因子 (HGF)等生长因子;辅助肝细胞分裂原如胰岛素和肾上腺素等;转化生长因子-β(TGF-β)等持续性肝细胞生 长抑制因子;生长抑制因子的抑制因子, 如:LAP(TGF-β N-末端肽段)等。前三类细胞因子分别对处在 G 期、 0 G 期、S期的肝细胞起直接或间接作用, 而后两类因子对前三种因子起到促进或者抑制的作用。本文旨在探 1 讨肝再生各主要相关细胞因子在肝再生过程中的作用机制以及它们之间的相互关系。 + + 【中图分类号】 329. 2 8;322 .4 7　【文献标识码】A　【文章编号】1006- 2947(2005)02 -0174 - 06 Exp loration of Cytok ines in L iver R egeneration LÜJing (Department of CellBiology, CapitalUniversity ofM edical Sciences, Beijing 100054 China) 【A b strac t】　Liver regeneration is a very complicated andmany regulation factors involved process, and many kinds of cytokines actvery mi portant roleson liver regeneration. These cytokines include prmi ing factors orproinflam- matory cytokines such as tumor necrosis factor alpha(TNF-α)and interleukin 6 (IL-6)etc, grow th factors like hep- atocyte growth factor (HGF)etc, comitogens such as insulin and epinephrine etc, tonic growth inhibitors including activinA and growth factor beta(TGF-β), suppressors of grow th inhibitors such asTGF-β inhibitor known as latency associated peptide (LAP)etc. The first three kinds of cytokines respectively affect on the heptocytes inG , G and S 0 1 phase;and the last wt o cytokines