钯催化羰基衍生物位的芳基化反应及其在天然产物合成中的应用.pdf

2005 25 Vol. 25, 2005 3 , 282289 Chinese Journal of Organic Chemistry No. 3, 282289 ·· α * ( 650091) α,α- α-α-,α-γ-Lycorane α-Cherylline, Latifine Physovenine ; ; ; ; α-; ; ; Palladium-Catalyzed α-Arylation of Carbonyl Derivatives and Its Applications in the Synthesis of Natural Products SHAO, Zhi-Hui ZHANG, Hong-Bin* (School of Pharmacy, Yunnan University, Kunming 650091) Abstract The progress in palladium-catalyzed α-arylation of carbonyl derivatives is reviewed with empha- sis on α-arylation of ketones, amides and esters. The applications of α-arylation of ketones in the synthesis of γ-lycorane as well as α-arylation of amides in the synthesis of natural products including cherylline, latifine and physovenine are also described. Keywords palladium-catalyzed; ketone; amide; ester; α-arylation; natural product; synthesis; application α . . α-, 1 α- [111]. . 1997 , 1. 1 α- Buchwald [12] [13] [12] [13] Hartwig , 1997 Buchwald Hartwig , α-. ,, α-(Eq. 1). , Natsume [18] [14] [15] α- α- α-α-. (Eq. 2). 1997, Miura [19a] , [16], . α- . [17] . Buchwald Pd2 (dba)3 α BINAP Tol-BINAP