急性白血病患者血清VEGF和LDH水平的测定及临床意义.pdf
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捅 要
盟检测急性自血病(AL)不同类型及不同阶段血清斑管内皮生长因子(vascular
endothelial
growthfactor,VEGr9和乳酸脱氢酶(1actate
者间关系及其在AL的病情监测、疗效观察及预后判断中的意义。
虚蘧 选取魅患者稻铡,其中初诊患者25铡,复发罐治患者勰德,28铡健康者
作为正常对照,分别用酶联免疫(EUSA)法测定患者血清VEGF,用速率法测定其赢清LDH
含量。所有数据均采用SPSSl3.0统计软件分析处理。
细胞计数(wBc)及m红蛋白∞)含量均无相关。
箜主鼓 初诊A己患者盘清VEGF及LDH水平魄显高予对照组,宠全缓解盛恢复至接
近正常,复发时再次升高,外周血ⅦGF和LDH水平与白觑病治疗疗效均呈正相关,故动
态检测血清VEGF及LDH水平可在一定程度上了解AL病情,对AL的疗效及预后判断有
一定的指导意义。
VEGF,LDH,
关键词 急性白血病, 临床意义
Abstract
measuretheserumvascularendothelialfactor(VEGF)andlactate
星坠£艘墼To growth
inacuteleukemia differentandto the
samples硒|lltypes explore
dehydrogenase(醢H)levels
betweenserum levelsandcurativeeffectsinacuteleukemia
relationship VEGF,LDH patients.
casesofacuteleukemia 25casesof leukemia
.M....e.。t。.h...o..d...s...45 patientsincluding primary
of
casesof and enrolledinthis levels
refractory study.Serum
patients,20relapse patients,were
VEGFandLDHweredetected immunoabsorbent automatic
byenzyme-linked assay【ELISA】and
VEGFandLDHlevelsinthevarious ofacuteleukemiawere
analyzer.The subtypes patients
and
contrastedtothoseofcontrol betweenthe levels the
VEGF,LDH
groups.relationship
cellswithinnucleatedcellsInbonemarrowandotherrelateditemswerealso
numbersoftheblast
datawere
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