comparative pathogenesis of three human and zoonotic sars-cov strains in cynomolgus macaques比较三个人类和人畜共患冠状病毒的发病机理猕猴猕猴.pdf

Comparative Pathogenesis of Three Human and Zoonotic SARS-CoV Strains in Cynomolgus Macaques 1,6 1 2 2 2 2 Barry Rockx *, Friederike Feldmann , Douglas Brining , Don Gardner , Rachel LaCasse , Lisa Kercher , 2 2 3 3 3 Dan Long , Rebecca Rosenke , Kimmo Virtaneva , Daniel E. Sturdevant , Stephen F. Porcella , John 4 2 5 1 Mattoon , Michael Parnell , Ralph S. Baric , Heinz Feldmann 1 Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, 2 Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, 3 Genomics Unit, Research Technologies Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, 4 Department of Veterinary Clinical Sciences, Washington State University, Pullman, Washington, United States of America, 5 Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, 6 Departments of Pathology and Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America Abstract The severe acute respiratory syndrome (SARS) epidemic was characterized by increased pathogenicity in the elderly due to an early exacerbated innate host response. SARS-CoV is a zoonotic pathoge