热休克蛋白与肿瘤的关系研究进展课件.pptx
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热休克蛋白与肿瘤的关系研究进展;;Definition of HSPs ;;5;Classification of HSPs;Biological functions of HSPs;;Hallmarks of Cancer;10;HSP90 and Tumor;HSP90 and Tumor;receptor proteins of HSP90;;;;HSP70 and Tumor;HSP70 and Tumor;HSP70 and Tumor;HSP70 and Tumor;Avoiding immune destruction;;Several conjectures;;;;27;HSP60 uses both innate and adaptive immune pathways to enhance regulatory T cell (Treg) function;;;HSP27的结构特点:
C 末端具有α-晶体结构域,氨基酸残基磷酸化水平的改变可调控 HSP27的聚合
N 末端是与分子标记蛋融合以对其进行观察并定位的结构基础
以寡聚体的形式存在,且具有不依赖ATP的伴侣蛋白功能;;;;HSP27 and Tumor;;37;;;;;热休克蛋白-抗原肽疫苗
(自体组织免疫激活素)
HSPgp96-肽复合物疫苗、HSP70-肽复合物疫苗;;;Thank you for
your listening!
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