自身免疫性肝病(Autoimmune liver disease).doc
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自身免疫性肝病(Autoimmune liver disease)
Autoimmune liver disease
(1) the etiology of AIH has not yet been fully elucidated, which may be the result of complex interactions such as induced factors, autogenic antigen, genetic susceptibility and immune regulation. The present circumstantial evidence suggests that AIH has a potential genetic predisposition background, in northern and north American populations, the main susceptible allele of type I AIH is hla-drbl 0301 and hla-drbl 0401. AIH may be associated with a variety of immune regulatory defects that control its own response; The occurrence of AIH in susceptible individuals may require an inducement, such as a hepatovirus infection, or specific reactions to drugs and other hepatotoxic substances. (4) the final effect mechanism of tissue injury may involve autoantibodies and expression in liver cells on the surface of the reaction of liver specific antigen (ADCC), and direct cytotoxic effects of T cells to liver cells appear relatively minor. (2) the PBC exact pathogenesis remains unclear, but think of bile duct injury is caused by the immunological disorders, now understand main complex (MHC) host susceptibility genes associated with the onset of the disease, mainly is the MHC Ⅱ type of molecular DR3 6 times, DR2 is higher than the control group. Many of the studies have been linked to infection, including infections in the gut, infection of mycobacterium mycobacterium, and infection of mycoplasma. Recently, it has been suggested that the possibility of retrovirus infection may even be useful in the treatment of primary biliary cirrhosis. (3) PSC is an unknown etiology of chronic bile stasis, which is characterized by intrahepatic and/or extrahepatic bile duct inflammation and fibrosis, and develops into cirrhosis of the liver. Several etiological hypotheses have been put forward, such as chronic portal bacteremia, the toxic effects of intestinal bacterial toxins or bile acid, chronic viral infection, ischemic vascular
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