郑钜圣 脂肪酸与糖尿病的关系.pdf

2015 DSM Science Technology Award China 2015 n-32 Association of dietary n-3 fatty acids with type 2 diabetes and other chronic diseases and related mechanisms Ju-Sheng Zheng PhD supervisor: Duo Li Department of Food Sci Nutr, Zhejiang University 201517 Background Type 2 Diabetes Breast Cancer n-3PUFA Heart disease Stroke Obesity Nonalcoholic fatty liver Meta-analysis n-3 PUFA Type 2 diabetes CHD Breast cancer 1n-32 n-3 fatty acids and type 2 diabetes Zheng et al, PLoS One 2012, 7(9):e44525 Database PubMed, Embase, Cochrane library, CNKI, VIP Search terms “fish” OR “seafood” OR “fatty acids” OR “docosahexaenoic acid” OR “eicosapentaenoic acid” OR “alpha-linolenic acid” AND “diabetes mellitus type 2” Inclusion criteria Prospective cohort and case-control study 1n-32 n-3 fatty acids and type 2 diabetes Flow chart 1n-32 n-3 fatty acids and type 2 diabetes n-32meta Meta-analysis of marine long-chain n-3 fatty acids with type 2 diabetes (highest vs lowest intake)