线粒体呼吸链与活性氧-生命科学.pdf
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20 4 Vol. 20, No. 4
2008 8 Chinese Bulletin of Life Sciences Aug., 2008
1004-0374(2008)04-0519-09
100101
1% 2%
(O
·)(H O )O · H O
2 2 2 2 2 2
Chance 20 70 90 20 90
(1)
O
2 ·
H2O2 ROS (2)III Q QO
(UQH·)O SHC
·C-P66 H O I
2 2 2
O
2 ·in vivo
O
·(3)O ·
2 2
O ·
2
H+
O ·HO · ,
2 2
O
·shuttling modelO ·UCPS (4)
2 2
∆P(∆ψ∆pH) ROS ()Q
Q O ·
O 2
∆P ATP
ROS
Q Q0 ROS ∆P ∆ψ ∆pH ROS
ROS Cyt C-p66Shc
Q493.8 A
Mitochondrial respiratory chain and reactive oxygen species
LIU Shu-sen
(State Key Laboratory of Biomembrane Membrane Biotechnology, Institute of Zoology,
Chinese Academy of Sciences, Beijing 100101,China)
Abstract: It has been established that most oxygen consumed b
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