synergy or independence deciphering the interaction of hla class i and nk cell kir alleles in early hiv-1 disease progression协同或独立解密hla的交互类hiv - 1月初我和nk细胞吉珥等位基因疾病进展.pdf

Opinion Synergy or Independence? Deciphering the Interaction of HLA Class I and NK Cell KIR Alleles in Early HIV-1 Disease Progression * Jason D. Barbour , Uma Sriram, Stacy J. Caillier, Jay A. Levy, Frederick M. Hecht, Jorge R. Oksenberg Introduction KIR3DS1 is a short-tailed form of KIR, and has very high sequence homology to KIR3DL1 in its extracellular domains. ndividual susceptibility to infectious disease, such as KIR3DS1 was predicted to likewise interact with Bw4Ile80 HIV-1, is strongly influenced by the genetic profile of the Ihost. Allelic variants of the human major molecules, although this interaction had not been directly observed. Martin et al. examined the epistatic interaction of histocompatibility complex (human leukocyte antigen [HLA]) KIR3DS1 and Bw4Ile80 for the effect on time to the onset of genes have been implicated repeatedly with susceptibility, AIDS [7] in a cohort of HIV-1-infected adults in North course, and outcome of HIV-1 infection [1]. The HLA Class I America. They observed that Bw4Ile80/KIR3DS1 carriers loci is genetically diverse, and in addition to its functions in experienced a significant delay in time to disease. The authors presenting peptide fragments of the invading pathogen to