association between clean delivery kit use, clean delivery practices, and neonatal survival pooled analysis of data from three sites in south asia联系清洁交付设备使用、清洁交付实践,和新生儿生存从三个站点的数据汇总分析表明在南亚.pdf

Association between Clean Delivery Kit Use, Clean Delivery Practices, and Neonatal Survival: Pooled Analysis of Data from Three Sites in South Asia 1 1 2 1 ¨ ¨ 1 Nadine Seward *, David Osrin , Leah Li , Anthony Costello , Anni-Maria Pulkki-Brannstrom , Tanja A. J. 1 1 3 3 4 5 Houweling , Joanna Morrison , Nirmala Nair , Prasanta Tripathy , Kishwar Azad , Dharma Manandhar , Audrey Prost1 1 UCL, Centre for International Health and Development, Institute of Child Health, United Kingdom, 2 UCL, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, United Kingdom, 3 Ekjut, Chakradharpur, Jharkhand, India, 4 Perinatal Care Project (PCP), Bangladesh, 5 Mother and Infant Research Activities (MIRA), Nepal Abstract Background: Sepsis accounts for up to 15% of an estimated 3.3 million annual neonatal deaths globally. We used data collected from the control arms of three previously conducted cluster-randomised controlled trials in rural Bangladesh, India, and Nepal to examine the association between clean delivery kit use or clean delivery practices and neonatal mortality among home births. Methods and Findings: Hierarchical, logistic regression models were used to explore the association between neonatal mortality and clean delivery kit use or clean delivery practices in 19,754 home births, controlling for confounders common to all study sites. We tested the association between kit use and neonatal mortality using a pooled dataset from all three sites and separately for each site. We then examined the association between individual clean delivery pract