L_精氨酸调节大鼠低氧性肺血管结构重建与肺动脉平滑肌细胞凋亡.pdf

( ) JOURNAL OF EKING UNIVERSITY( HEALTH SCIENCES) Vol. 33No. 4Aug 2001 339 L-精氨酸调节大鼠低氧性肺血管结构重建与 肺动脉平滑肌细胞凋亡 1 1 1 2 1 1 3 齐建光 , 杜军保 , 郭志良 , 赵斌, 张清友 , 曾和平, 唐朝枢 ( 1 1 ; 3 , 100034; 2 ) [ ] / ; ; ; ; , , / [ ] 目的: L-( L-arginine, L-Arg) 方法: 17 Wistar ( n = 7) ( n = 5) + L-Arg ( n = 5) dUT (TUNEL) , Fas 结果: 2 , ( P 0. 05 ) , Fas , L-Arg + L-Arg ( P 0.05 ) L-Arg Fas 结论: L-Arg Fas , , [ ] R972-332 [ ] A [] 1671- 167X( 2001) 04-0339-05 L-arginine regulates hypoxic pulmonary vascular structural remodeling and pulmonary artery smooth muscle cell apoptosis in rats 1 1 1 2 1 1 QI Jian-Guang , DU Jun-Bao , GUO Zh-i Liang , ZHAO Bin , ZHANG Qin-You ,ZENG He- ing , TANG Chao-Shu ( 1Department of ediatrics, 3. Institute of Cardiovascular Research, eking University First Hospital, Beijing 100034, China; 2 Department of Internal, Medical Jishuitan Hospital, Beijing) KEY WORDSArginine/ pharmacol; ulmonary artery; Cell hypoxia; Apoptosis; Muscle, smooth vas- cular/ drug eff SUMMARY O jective: To explore the impact of L-arginine ( L-Arg ) on apoptosis of smooth muscle cells in pulmonary arteries of the rats with hypoxic pulmonary vascular structural remodeling. Meth- ods: Seventeen Wistar rats were randomly divided into hypoxia group ( n = 5 ) , hypoxia with L-argi- nine group ( n = 5 ) and control group ( n = 7 ) . ulmonary vascular microstructure was measured under a light microscope. Apoptotic smooth muscle cells in pulmonary arteries were detected by TdT- mediated dUT -biotin nick end labeling ( TUNEL ) , and the expression of Fas protein by pulmonary artery smooth muscle c