雷奈酸锶对模拟失重雄性大鼠骨质疏松防治作用.PDF

窑834 窑 南方医科大学学报(JSouthMedUniv) 2010;30(4) 雷奈酸锶对模拟失重雄性大鼠骨质疏松的防治作用 1 2 1 1 1 1 1 1 1 2 杨 锐 袁黄 震 袁蔡德鸿 袁张 桦 袁赖阿娜 袁张 振 袁孙 平 袁陈 宏 (南方医科大学珠江医院 内分泌科袁 外科 学教研室袁广东 广州 510282) 摘要院目的观察雷奈酸锶对模拟失重雄性大鼠质疏松的影响遥 方法雄性SD大鼠27 只袁随机平均分为3组:A组为对 照组袁B组为尾吊模拟失重组袁C组为悬吊模拟失重同时给以雷奈酸锶灌胃组遥 A 和B组灌等量生理盐水袁各组实验期 均为28d遥 测骨代谢指标袁右侧股骨的骨密度和骨矿盐含量袁扫描电镜观察股骨颈超微结构遥 结果B组大鼠血清碱性 磷酸酶尧骨密度尧骨矿盐含量水平显著低于A 组相应的指标(P0.05)袁血钙尧血磷无显著差异渊P0.05冤袁组骨小梁表面胶 原纤维排列杂乱袁松散袁可见骨吸收现象曰C组大鼠上述生化及代谢指标显著性高于B组大鼠(P0.05)袁C组大鼠骨小梁 较B组数量增多袁厚度增加袁骨吸收减少遥 结论雷奈酸锶能明显降低模拟失重大鼠股骨颈的骨丢失袁增加骨形成袁防治 骨质疏松症遥 关键词院雷奈酸锶曰模拟失重曰骨质疏松曰骨密度曰生化指标曰扫描电镜 中图分类号院R34 文献标识码院A 文章编号院1673-4254(2010)04-0834-04 Preventiveandtherapeutieeffectofstrontiumranelateonosteoporosisinratssubjectedto simulatedweightlessness 1 2 1 1 1 1 1 1 YANGRui ,HUANGZhen,CAIDe-hong,ZHANGHua ,LAIA-na,ZHANGZhen ,SUNPing,CHENHong 1 2 DepartmentofEndocrinology, SurgeryTeachingandResearchSection, ZhujiangHospital, SouthernMedicalUniversity, Guangzhou 510282 Abstract: Objective Tostudytheeffectsofstrontiumranelateonosteoporosisinducedbysimulatedweightle ne inmale rats. MethodsTwenty-sevenmaleSDratswererandomlydividedinto3groups,namelythenormalcontrolgroup(groupA) andtwogroupsofweightle ne imulatedbytailsuspension (groupsBandC). TheratsingroupCweretreatedwith strontiumranelate, andthoseintheothertwogroupsweregiventhesamedoseofnormalsalinefor28consecutivedays. Results TheratsingroupBshowedsignificantlylowerlevelsofalkalinephosphatase (ALP), bonemineraldensity (BMD) andbonemineralcontent (BMC) thanthoseingroupA (P0.05), butserumcalciumandphosphoniumconcentration underwentnosignificantchangesinthe3groups(P0.05).IntheratsofgroupB,thetrabeculaeofthefemurbecamethinner, frag