新型固碳途径—羟基丙酸循环的研究进展.PDF

微生物学通报 Feb. 20, 2013, 40(2): 304−315 Microbiology China © 2013 by Institute of Microbiology, CAS tongbao@ 专论与综述 新型固碳途径—3-羟基丙酸循环的研究进展 王洪杰 倪俊 张怡 张玲 辛越勇* (杭州师范大学 生命与环境科学学院 浙江 杭州 310036) 摘 要: 3-羟基丙酸循环是一种存在于嗜热光合绿丝菌中新型的CO2 固定途径。此循环的 特征代谢中间物为 3-羟基丙酸, 该化合物可用于合成许多重要的化工产品, 具有很高的 工业价值。本文介绍了 3-羟基丙酸循环固碳途径的发现、反应机理的逐步阐明过程及最 新的研究进展, 并对其理论意义和在绿色化工中的应用前景进行了探讨。 关键词: CO2 固定途径, 3-羟基丙酸循环, 嗜热光合绿丝菌, 多功能酶, 生物合成 The progress of studies on a unique carbon dioxide fixation pathway: 3-hydroxypropionate cycle * WANG Hong-Jie NI Jun ZHANG Yi ZHANG Ling XIN Yue-Yong (College of Life and Environmental Sciences, Hangzhou Normal University , Hangzhou , Zhejiang 310036, China) Abstract: A novel carbon dioxide fixation pathway, 3-hydroxypropionate cycle, has been dis- covered in thermophilic filamentous photosynthetic bacteria such as Chloroflexus aurantiacus, which can grow in several conditions. The characteristic of this pathway is 3-hydroxypropionate as a metabolic intermediate, which can be used for synthesis of many valuable products in industry. In this minireview, the discovery of this unique biosynthetic process, the development of the reaction mechanism and the latest progress are introduced, especially the involvement of several multifunction enzymes. Besides theoretical significance, potential biotechnological applications of the 3-hydroxypropionate pat