术毕单次注射帕瑞昔布钠对布托啡诺早期镇痛效果的影响.pdf

．『临r-A研究． 术毕单次注射帕瑞昔布钠对布托啡诺早期镇痛 效果的影响 蒋金娣桂波王美青王灿琴钱燕宁 【摘要】 目的观察术毕单次沣射帕瑞昔布钠是否增强布托啡诺的早期镇痛效果。方法 拟 rain 行扦期腹部手术的患者60例．随机均分为帕瑞昔布钠组(P组)和对照组(B组)，均在术毕前30 静注布托啡诺0．015mg／kg、昂丹司琼8mg．术后行PCIA(布托啡诺0．15mg／kg、昂丹司琼16mg 稀释至100m1)；P组术毕前30rain同时静注帕瑞昔布钠40mg。记录术后4、24、48h的疼痛VAS 评分、Ramsay镇静评分、追加镇痛药例数、镇痛泵按压次数和不良反应发生情况。结果P组术后4 h镇痛泵按压次数明显少于B组(PO．05)。术后4h， h的VAS评分、追加镇痛药人数及术后4、24 P组有2例需追加镇痛药，显著少于B组(12例)(PO．01)。两组术后恶心呕吐、头晕等不良反应差 异无统计学意义。结论术毕前加用帕瑞昔布钠可增强单用布托啡诺镇痛时的术后早期镇痛效果， 未增加不良反应发生率。 【关键词】 布托啡诺；帕瑞昔布钠；静脉自控镇痛 Effectofa doseof sodiumattheendof onthe single parecoxibgiven operationearlyanalgesicefficacy with JIANG Jin-di，GUI130，WANG Yah—ning． butorphanol Mei—qing．WANGCan-qin，QIAN First of Medical DepartmentofAnesthesiology，TheAffiliatedHospitalNanjing University，Nanjing 210029．∞ina author：QIANYon—ning，E-mail：yanningqian@yahoo．corn．cn Corresponding end To whethera doseof sodiumatthe [Abstract]Objectiveinvestigate single parecoxibgiven of could the with operationimproveearlyanalgesicefficacybutorphano[．MethodsSixtypatients scheduledforelectiveabdominalwere dividedintotwo sodium surgeryrandomly groups：pareeoxib P)andcontrol B)，with30cases 0．015 and group(group group(group each．Butorphanolmg／kg ondansetron8 were inboth while Sodium40 was mg given groups parecoxib mg simultaneously administered in Pat30minbeforetheendofthe received intravenouslygroup operation．Bothgroups intravenous with O．15 andondansetron16 diluted pa