血管内皮生长因子研究进展及其与胰腺癌的相关研究-海南医学.pdf

Hainan Med J, Apr. 2014, Vol. 25, No. 8 海南医学2014年4月第25卷第8期 doi:10.3969/j.issn.1003-6350.2014.08.0448 ·综 述· 血管内皮生长因子研究进展及其与胰腺癌的相关研究 杨小秋，谈 顺 ( 中南大学湘雅医学院附属海口医院病理科，海南 海口 570208) 【摘要】 在胰腺癌的生长和转移中新生血管形成（Angiogenesis ）是其从小结节进展成为具有侵袭能力重要 的一步。血管内皮生长因子是肿瘤血管新生过程中最重要的驱动因子，血管新生的主要调节者。随着VEGF 途 径作用机制研究的日益深入，VEGF 与胰腺癌的关系也受到越来越多的关注。本文从VEGF 的结构和功能、调控 因素及相关调控机制，VEGF 在胰腺癌中表达的临床意义，以及抗VEGF 治疗在胰腺癌中的相关研究进展方面， 对VEGF 在胰腺癌中的研究现状做一介绍。 【关键词】 血管内皮生长因子；胰腺癌；抗VEGF 治疗 【中图分类号】R735.9 【文献标识码】A 【文章编号】 1003—6350（2014 ）08—1157 —04 Researchprogressofvascularendothelialgrowthfactorinpancreaticcarcinoma. YANGXiao-qiu,TANShun. DepartmentofPathology,AffiliatedHaikouHospitalofXiangyaSchoolofMedicine,CentralSouthUniversity,Haikou 570208,Hainan,CHINA 【Abstract】 In the growth and metastasis process of pancreatic carcinoma, angiogenesis is a vital step which makes the tumor have the ability of metastasis from a small nodule. Vascular endothelial growth factor (VEGF) is viewed as a cru- cial driving factor and the major regulator in the process of angiogenesis. With the deepening research of the mechanism of VEGF pathway, studies on VEGF and pancreatic cancer have become a focusing topic. Therefore, the relationship between VEGF and pancreatic carcinoma is reviewed in this article. Then, we summarized the recent findings from the following as- pects: the characteristics of VEGF (including the structure and function, modulating factors and regulation mechanism), the clinical significance of VEGF and anti-VEGF therapy in pancreatic carcinoma. 【Keywords】 Vascular endothelial growth factor (VEGF); Pancreatic carcinoma; Anti-VEGF therapy