婴幼儿急性特发性血小板减少性紫癜及巨细胞病毒感染相关性探析.doc

婴幼儿急性特发性血小板减少性紫癜及巨细胞病毒感染相关性探析 　　[摘要] 目的 探讨婴幼儿急性特发性血小板减少性紫癜与巨细胞病毒感染的相关性。 方法 将2011年2月～2015年2月于我院进行治疗的120例ITP婴幼儿作为观察组，再根据是否感染巨细胞病毒将其分为感染组与未感染组，同时选择60例健康婴幼儿作为对照组，分别对两组婴幼儿的检测及治疗数据进行统计对比分析。 结果 观察组婴幼儿中血清CMV-DNA、血清CMV-IgM以及血清CMV-IgG呈阳性的占比明显高于对照组婴幼儿；感染组婴幼儿的平均血小板计数明显低于未感染组婴幼儿的平均血小板计数；治疗后给予更昔洛韦治疗婴幼儿的末梢血血小板数量明显多于给予常规治疗婴幼儿的末梢血血小板数量。 结论 CMV是ITP婴幼儿的主要发病因素之一，更昔洛韦是ITP婴幼儿治疗的对症药物 [关键词] 婴幼儿；急性特发性血小板减少性紫癜；巨细胞病毒；感染 [中图分类号] R725.5 [文献标识码] B [文章编号] 1673-9701（2017）08-0051-03 [Abstract] Objective To investigate the correlation between acute idiopathic thrombocytopenic purpura and cytomegalovirus infection in infants and young children. Methods 120 cases of ITP infants and young children treated in our hospital from February 2011 to February 2015 were treated as the observation group. And then according to whether the infection of cytomegalovirus or not， they were divided into infected group and uninfected group. At the same time， 60 infants and young children were chosen as the control group. The detection and treatment data between the two groups were statistically analyzed. Results The positive rates of serum CMV-DNA， serum CMV-IgM and serum CMV-IgG in the observation group were significantly higher than those in the control group. The average platelet count in the infected group was significantly lower than that in the uninfected group. After treatment， peripheral blood platelet count of infants and young children treated with ganciclovir was significantly more than that of infants and young children given routine treatment. Conclusion CMV is one of the main risk factors of infants and young children with ITP. Ganciclovir is a symptomatic drug for infants and young children with ITP. [Key words] Infants and young children； Acute idiopathic thrombocytopenic purpura； Cytomegalovirus； Infection 急性特?l性血小板减少性紫癜是婴幼儿常见的出血性疾病[1]，临床特征主要为血小板减少、出血时间延长及血块收缩不良等[2]，严重时会导致婴幼儿骨髓中的巨核细胞发育被抑制，如果治疗不及时或不恰当则可能转为慢性特发性血小板减少性紫癜，不仅会给婴幼儿带来更多的痛苦，还会对婴幼儿的身心造成严重影响，对婴幼儿的健康成长十分不利。目前急性特发性血小板减少性紫癜的发病机制尚未完全明确，