无细胞接触条件下成人骨髓间充质干细胞培养上清对异体淋巴细胞增殖的负调控作用.pdf

中国组织工程研究与临床康复 12眷 43 2008—10—21出版 JournalofClinic．zRehabilitativeTissueEngineeringResearchOctober21，2008Vol12No4·3 死 胁fc 捌 Negativelyregulatoryeffectsofbonemarrow-d·erived mesenchymalstem cellssupernatantonallogeneic lymphocytesproliferation冰冰★ wu-I-ao ，E；hiJing—yun，BaiHal’WangCun-bang ，LuJi-hong’OuJian-feng’ ， ， Abstract BACKGROUND：Preliminarystudyhasproventhatadulthumanbonemarrow—derivedmesenchymalstemcells(MSCs)suppress HematologyCenter of ChinesePLA． peripheralbloodlymphocytesproliferation．Butthemechanism wasstilItobeinvestigated． LanzhouGeneral OBJECTIVE：TostudythenegativelyregulatoryeffectofadulthumanMSCsonallogeneiclymphocyteproliferationbycell—free HospitalofLanzhou condition． M ilitaryArea DESIGN．TIME AND SETTING：Cytologicalobservationinvitro，whichwasperformedintheLanzhouGeneralHospital， CommandofChinese LanzhouMilRaryAreaCommandofChinesePLAbetweenOctober2005andDecember2007． PLA，Lanzhou MATERIALS：Thebonemarrow samplewasprovidedbytheallo—transplantationdonor．Theperipheralbloodlymphocyteswere