Ru催化的C-H键的活化反应.pdf

】幻2年第刀卷 有机 化 学 vi 刀 第5期，307一3价 口山useJ.-tofOgxnicChemise. N0 5。320瞥7 ·综述与进展 · Ru催化的C-H键的活化反应 余世超 麻生明 ‘ 062 八 (中国科学院上海有机化学研究所金属有机化学国家重点实验室 上海 2t1Q刀2) 摘要 概述了Ru催化的碳氢键的活化反应，包括C-H/烯烃，C-H/炔烃和C-H/CO/姆烃偶联反应 加氢酸化反 应，硅化反应. 关扭词 Ru催化剂，C-H键，活化反应，偶联反应，加氢阮化，硅化 ActivationReactionsofRu-CatalyzedArylicorOlefinicC-HBonds YU,Shi-Chap MA,Sheng-M吨 (StarKeylab-,y ofOgIh,Ch- to，ShanghaiJwdtuteofOrgawChemiatr)， LRiruseAcademyofS- ,Shanghai200032) Abstract hithelastfewyears,muchhasbeenlearnedaboutthetransitionmetal-catalyzedactivationofarylic orolefinicC-Hbonds.AnimportantextensionofthesereactionssuchasC-H/olefrn,C-H/acetylene, C-H/COandC-H/CO/olefmcouplings,hydmacylationandsilylationcanberegardedaspracticaltools,for thesereactionsexhibithighselectivity,highefficiencyandwideapplicability.EspeciallytheC-H/CO/olefin couplingprotocolcanbeausefulcomplementarymethodtoFriedel-Craftsreaction,sinceittakesplaceeven whentherereelectron-withdrawinggroupsinthearylgroupsofsubstrates.Inthesereactionsthecoordination ofthesubstratestotherutheniumcenterinthecatalystcomplexisanecessaryprerequisiteforthereactionsto proceed.Inthispaper,wellsurveytheRu-catalyzedfunctionalizationsofC-Hbondsthatwerepublished叩 totheendof2000.Thesecatal州。reactionsinvolveastepofnucleophilicaddition场arutheniumcomplex. Thefactorsaffectingtheselectivityshown场differentcatalystsarealsodiscussed. Keywordsrothemumcomplex,C-Hbond,activation,coupling,hydroacylation,silylation 过渡金属催化的碳氢键的活化反应是近年来化 及△ ‘“值如Scheme2所示(R二ph)[21. 学上的一大热点，正越来越引起人们的广泛兴趣r「1