乙肝病毒表面抗原阳性孕妇母婴阻断效果评价及影响因素分析.docx
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【摘要】目的:分析乙肝病毒表面抗原(HBsAg)阳性孕妇母婴阻断效果及相关影响因素。方法:收集2020年1月—2023年12月惠山区预防梅毒、乙肝母婴传播工作月报表和乙肝表面抗原阳性孕产妇及所分娩儿童服务情况一览表,对222例HBsAg阳性孕妇及所分娩新生儿的资料进行分析,儿童8月龄之后采集血液,检测儿童乙肝血清学指标评价母婴阻断效果,采取单因素与多因素Logistic回顾分析阻断效果的相关影响因素。结果:222例儿童25例(11.26%)HBsAg阳性,201例(90.54%)抗-HBs阳性,10例(4.50%)抗-HBc阳性。多因素Logistic回归分析显示HBsAg阳性持续时间长(OR=1.562)、未同时接种乙肝疫苗与乙肝免疫球蛋白(OR=2.041)和母乳喂养(OR=1.884)均是HBsAg阳性孕妇母婴阻断效果的危险因素。结论:HBsAg阳性孕妇的母婴阻断效果受HBsAg阳性持续时间、未同时接种疫苗和免疫球蛋白、母乳喂养等因素影响。
【关键词】乙肝病毒表面抗原;阳性;孕妇;母婴阻断;影响因素
Evaluationofmother-to-childblockadeeffectofHBsAgpositivepregnantwomenandanalysisofinfluencingfactors
WANGZhe
MaternalandChildHealthandFamilyPlanningServiceCenterofHuishanDistrict,WuxiCity,Wuxi,Jiangsu214100,China
【Abstract】Objective:Toanalyzethemother-to-childblockadeeffectofhepatitisBvirussurfaceantigen(HBsAg)positivepregnantwomenandrelatedinfluencingfactors.Methods:ThemonthlyreportonthepreventionofsyphilisandhepatitisBmother-to-childtransmissioninHuishanDistrictfromJanuary2020toDecember2023andthelistofservicesforhepatitisBsurfaceantigen-positivepregnantwomenandtheirchildrenwerecollected,andthedataof222HBsAg-positivepregnantwomenandtheirnewbornswereanalyzed,andthebloodwascollectedaftertheageof8months,andtheserologicalindexesofhepatitisBinchildrenweretestedtoevaluatethemother-to-childblockingeffect,andtherelevantinfluencingfactorsoftheblockingeffectwereanalyzedbyunivariateandmultivariatelogisticretrospectively.Results:25cases(11.26%)of222childrenwereHBsAgpositive,201cases(90.54%)werepositiveforantiHBs,and10cases(4.50%)werepositiveforanti-HBc.MultivariateLogisticregressionanalysisshowedthatthelongdurationofHBsAgpositivity(OR=1.562),nosimultaneousvaccinBc4rlH+wLqN1jb5sJv6/nXv1PJQbicCjZgwUidQyhJY=ationofhepatitisBvaccineandhepatitisBimmuneglobulin(OR=2.041),andb