血清内皮细胞特异性分子―1和冠状动脉病变相关性研究.doc

血清内皮细胞特异性分子―1和冠状动脉病变相关性研究 　　摘要：目的 内皮细胞特异性分子-1是近年来发现的新型内皮功能紊乱生物标记物，内皮功能紊乱在冠心病发病过程中起了重要作用，本研究探讨冠心病患者入院血清ESM-1表达水平及与冠状动脉病变及其严重程度的关系。方法 对130例行冠状动脉造影检查患者，按造影结果分为冠心病组（70例）和对照组（非冠心病组，60例），对所有入组患者进行血清ESM-1检测。比较两组患者血清ESM-1表达水平，同时，对冠心病组中将不同亚组患者的血清ESM-1水平进一步比较。结果 与对照组比较，冠心病组ESM-1水平较高[（1.31±0.72） ng/ml vs （1.09±0.14） ng/ml， P0.05]、冠心病亚组中，多支血管病变者血清ESM-1水平明显高于单支血管病变组，差异有统计学意义（P0.05）。结论 冠心病患者血清ESM-1水平高于对照组，ESM-1可能是冠心病患者内皮功能紊乱新型生物标记物，其表达水平且随血管病变程度加重而增高。 　　关键词：冠心病；内皮细胞特异性分子-1；生物标记物 　　中图分类号：R542.22 文献标识码：A 文章编号：1006-1959（2017）25-0179-02 　　Abstract：Objective Endothelial cell-specific molecule-1 is a new biomarker of endothelial dysfunction found in recent years.Endothelial dysfunction plays an important role in the pathogenesis of coronary heart disease.This study was to investigate the relationship between serum ESM-1 expression in patients with coronary heart disease and the severity of coronary artery disease.Methods 130 patients undergoing coronary angiography were divided into coronary heart disease group（70 cases）and control group（non-coronary heart disease group，60 cases）according to the results of angiography.Serum ESM-1 was detected in all patients.Serum ESM-1 levels were compared between the two groups，meanwhile，serum ESM-1 levels in different subgroups were further compared in CHD group.Results Compared with the control group，the ESM-1 level in CHD group was significantly higher than that in the control group[（1.31±0.72）ng/mL vs（1.09±0.14）ng/mL，P0.05]，In the coronary heart disease subgroup，the level of ESM-1 in the multivessel disease group was significantly higher than that in the single vessel disease group（P0.05）.Conclusion The level of serum ESM-1 in patients with coronary heart disease is higher than that in the control group.ESM-1 may be a new biomarker of endothelial dysfunction in patients with coronary heart disease.The level of ESM-1 expression is increased with the severity of vascular disease. 　　Key words：Coronary heart disease；Endothelial cell-specific mo