study on the stability of deoxyarbutin in an anhydrous emulsion systemy研究无水乳液systemy deoxyarbutin的稳定性.pdf

Int. J. Mol. Sci. 2011, 12, 5946-5954; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Study on the Stability of DeoxyArbutin in an Anhydrous Emulsion System Chih-Chien Lin 1,*, Chao-Hsun Yang 1, Nai-Fang Chang 1, Pey-Shiuan Wu 1, Yi-Shyan Chen 1, 2 1 Shu-Mei Lee and Chiu-Wen Chen 1 Department of Cosmetic Science, Providence University, 200 Chung-Chi Road, Shalu, Taichung 43301, Taiwan; E-Mails: chyang@.tw (C.-H.Y.); nfchang@.tw (N.-F.C.); jwu2@.tw (P.-S.W.); yishyan@.tw (Y .-S.C.); rita770115@ (C.-W.C.) 2 Department of Cosmetic Science and Management, Mackay Medicine, Nursing and Management College, 92 Shengjing Road, Beitou, Taipei 11260, Taiwan; E-Mail: s107@.tw * Author to whom correspondence should be addressed; E-Mail: chchlin@.tw; Tel.: +886-4ext. 15409; Fax: +886-4 Received: 3 August 2011; in revised form: 1 September 2011 / Accepted: 7 September 2011 / Published: 15 September 2011 Abstract: The skin-whitening agent, deoxyArbutin, is a potent tyrosinase inhibitor that is safer than hydroquinone and arbutin. However, it is thermolabile in aqueous solutions, where it decomposes to hydroquinone. Pharmaceutical and cosmetic emulsions are normally oil-in-water (o/w) or water-in-oil (w/o) systems; however, emulsions can be formulated with no