uropathogenic escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide ll-37uropathogenic大肠杆菌调节免疫反应及其curli菌毛与抗菌肽ll-37交互.pdf

Uropathogenic Escherichia coli Modulates Immune Responses and Its Curli Fimbriae Interact with the Antimicrobial Peptide LL-37 1a ¨ 2a 2,3 4 4 ˚ 2 Ylva Kai-Larsen , Petra Luthje , Milan Chromek , Verena Peters , Xiaoda Wang , Asa Holm , Lavinia ´ 2 5 6 7 8 ¨ 4 Kadas , Kjell-Olof Hedlund , Jan Johansson , Matthew R. Chapman , Stefan H. Jacobson , Ute Romling , Birgitta Agerberth1b, Annelie Brauner2*b 1 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 2 Department of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 3 Department of Pediatrics, CLINTEC, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, 4 Department of Microbiology, Tumor and Cell Biology, Stockholm, Sweden, 5 Swedish Institute for Infectious Disease Control, Solna, Sweden, 6 Department of Anatomy, Physiology and Biochemistry, SLU, The Biomedical Centre, Uppsala, Sweden, 7 Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America, 8 Department of Nephrology, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden Abstract Bacterial growth in multicellular communities, or biofilms, offers many potential advantages over single-cell growth, including resistance to antimicrobial factors. Here we describe the interaction between the biofilm-promo