the birth weight lowering c-allele of rs900400 near lekr1 and ccnl1 associates with elevated insulin release following an oral glucose challenge附近的出生体重降低c-allele rs900400 lekr1 ccnl1 associates和胰岛素释放后口服葡萄糖升高的挑战.pdf

The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge 1 1 2 3 ˇ ´ ´4 Ehm A. Andersson , Marie N. Harder *, Kasper Pilgaard , Charlotta Pisinger , Alena Stancakova , 4 1 2 2 2 Johanna Kuusisto , Niels Grarup , Kristine Færch , Pernille Poulsen , Daniel R. Witte , Torben 3,5 2,6 4 1,7,8,9 1,10 Jørgensen , Allan Vaag , Markku Laakso , Oluf Pedersen , Torben Hansen 1 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, 2 Steno Diabetes Center, Gentofte, Denmark, 3 Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark, 4 Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland, 5 Department of Public Health, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark, 6 Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark, 7 Institute of Biomedical Science, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, 8 Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark, 9 Hagedorn Research Institute, Gentofte, Denmark, 10 Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark Abstract Background and Aim: The first genome-wide association study on birth weight was recently published and the most significant assoc