天然产物中乙酰胆碱酯酶抑制剂的研究现状.pdf

11 1 ( ) Vol. 11 No. 1 2011 3 JOU RNA L OF SHANGHAI INST ITU T E OF T ECHNOLOGY(N ATU RAL SCIEN CE) Mar. 2011 : 1 71- 7333(2011) 01- 0001- 0 1 2 2 张赟彬 , 宋 庆 , 胡刘岩 ( 1. , 200235; 2. , 200234) : 抑制乙酰胆碱酯酶( AChE) 是目前治疗阿尔茨海默氏病( AD) 最有效的方 , 而丰富 的自然资源是开发乙酰胆碱酯酶抑制剂的宝库介绍了作为开发乙酰胆碱酯酶抑制剂的天然 产物的研究现状, 归纳了一些重要的具有乙酰胆碱酯酶抑制剂的植物种类植物中抑制AChE 的活性成分以及一些微生物来源的乙酰胆碱酯酶抑制剂 : 乙酰胆碱酯酶; 阿尔茨海默氏病; 乙酰胆碱酯酶抑制剂; 天然产物 : R 971 : A Current Situation in the Research of Acetylcholinesterase Inhibitors from Natural Products 2 1 2 ZHANG Yunbin , SONG Qing , HU Liuyan (1. School of Perfume andAroma Technology, Shanghai Institute of Technology, Shanghai 200235, China; 2. College of Life andEnvironment Sciences, Shanghai Normal niversity, Shanghai200234, China) Abstract:Inhibition of acetylcholinesterase (AChE) is considered as the most significant strategy for thetreatment of Alzheimers disease(AD) at present.And the abundance of natural productsis a treas ure for developing acetylcholinesterase inhibitors. The article reviews the current situation in the re search of acetylcholinesterase inhibitiorsfrom natural products.Numerous phytoconstituents,promising plant species and microorganismsas AChE inhibitors are reported in this paper. Key words: acetylcholinesterase; alzheimersdisease; acetylcholinesterase inhibitiors; natural products ( acetylchlinesterase, A ChE) ( Alzheimers , FDA Disease ,AD), AChE , 4 , , FDA , : Tacrine() [1] , Donepezil()Rivastigmine()Ga , AD lantamine ()[3,4] ,