中山大学-高雄医学大学.ppt

參與研究成員與工作分配 中山大學 莫顯蕎老師、魏瑞昌老師:音樂轉換與分析 中山大學 李美文老師、翁佳芬老師:音樂選擇 高雄醫學大學 謝寶森老師:動物行為分析 高雄醫學大學 附設醫院 楊瑞成醫師、林龍昌醫師:音樂治療機轉之分子生物學探討 高雄醫學大學 附設醫院 楊生湳醫師:老鼠缺氧模型之建立 Thanks for your attention ! 中山大學-高雄醫學大學跨領域學術合作會議 高雄醫學大學附設醫院 小兒科 林龍昌醫師 Effect of Music on developing brain Outline Music and neuronal plasticity Music and neurotransmitter Medical application of music Research aim Music and neuronal plasticity Ann. N.Y. Acad. Sci 2009 Music and neuronal plasticity MIDI-piano or electronic drum pads for 3 weeks enhance fine and gross motor recovery as well as electrophysiological changes in 32 patients of stroke. This suggests that music-making might be an effective means to induce plastic changes in the motor system. Ann. N.Y. Acad. Sci 2009 Investigate structural brain changes in relation to behavior changes in young children who received 15 months of instrumental musical training. Instrumental children showed improvement on finger motor task and the melody/rhythmic tasks. Clinical Medicine 2008 Length of precentral gyrus is longer in keyboard players relative to non-musician controls. Professional musicians who commenced their training before age seven were found to have a larger anterior portion of the corpus callosum compared to non-musician controls. Music and neurotransmitter Neuroscience letters 2007 GluR2, a major subunit in AMPA receptor, participate in plastic changes in the efficacy of synaptic transmission underlying learning, memory, and formation of neural networks. Brain research 2007 Fertilized eggs of chicks were exposed to either species-specific calls or sitar music at 65 dB for 15min/h round the clock from embryonic day 10 until hatching. Hippocampus of developmental stages (E12, E16, and E20) were examined. The hippocampus showed an increase in its volume, total number of neurons and levels of expression of calbindin D-28K and parvalbumin. Calbindin D-28K and parvalbumin are the markers of neuronal differentiation and outgrowth. Prenatal auditory s