spirochaetes as intestinal pathogens lessons from a brachyspira genome螺旋体属作为brachyspira基因组肠道病原体的教训.pdf

Gut Pathogens BioMed Central Commentary Open Access Spirochaetes as intestinal pathogens: Lessons from a Brachyspira genome 1 2 David J Hampson* and Niyaz Ahmed* 1 Address: Animal Research Institute, School of Veterinary and Biomedical Science, Murdoch University, Murdoch, Western Australia 6150, Australia and 2Department of Biotechnology, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India Email: David J Hampson* - d.hampson@.au; Niyaz Ahmed* - ahmed.nizi@ * Corresponding authors Published: 1 May 2009 Received: 23 April 2009 Accepted: 1 May 2009 Gut Pathogens 2009, 1:10 doi:10.1186/1757-4749-1-10 This article is available from: /content/1/1/10 © 2009 Hampson and Ahmed; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Anaerobic spirochaetes of the genus Brachyspira have long been known as important gut pathogens of pigs, but increasingly they are recognised as causing disease in birds and other animal species, including human beings. The genome sequence of the major swine pathogen Brachyspira hyodysenteriae was recently published, and this revealed extensive genome optimisation that leads