the effect of two different oxytetracycline treatments in experimental ehrlichia phagocytophila infected lambs两个不同的氧四环素治疗的效果在实验埃立克体属phagocytophila感染的羊羔.pdf

Acta vet. scand. 2001, 42, 339-346. The Effect of Two Different Oxytetracycline Treatments in Experimental Ehrlichia phagocytophila Infected Lambs By S. Stuen1 and K. Bergström2 1 Norwegian School of Veterinary Science, Department of Sheep and Goat Research, Sandnes, Norway and 2National Veterinary Institute, Department of Bacteriology, Uppsala, Sweden. Stuen S, Bergström K: The effect of two different oxytetracycline treatments in ex- perimental Ehrlichia phagocytophila infected lambs: Acta vet. scand. 2001, 42, 339- 346. – The effect of 2 different oxytetracycline treatments in acute E. phagocytophila in- fected lambs was investigated. Twenty 5-month-old lambs of the Dala and Rygja breeds were used. Ten lambs were inoculated intravenously with a stabilate of an ovine E. phagocytophila strain. On the third day of fever, 4 lambs were given long-acting oxyte- tracycline (Terramycin prolongatum vet®, Pfizer) (20 mg/kg) intramuscularly and an- other 4 lambs were given short-acting oxytetracycline (Terramycin vet®, Pfizer) (10 mg/kg) intravenously for 5 consecutive days. The lambs were examined for the presence of Ehrlichia infection by blood smear evaluation, polymerase chain reaction (PCR) and antibody titre against E. equi. One month after the last antibiotic treatment, 250 ml cit- rate blood from each of these lambs were inoculated into each of 10 susceptible lambs, which were observed during the following 6 weeks. The results indicate that oxytetra- cycline given in the acute stage of the infection may effectively teminate the develop- ment of fever, rickettsemia and weight reduction in E. phagocytophila infected lambs. No difference was observed bet