《《aiming for ideal synthesis》.pdf
文本预览下载声明
/joc
Aiming for the Ideal Synthesis
Tanja Gaich and Phil S. Baran*
Department of Chemistry, The Scripps Research Institute, 10550North TorreyPines Road, 92037La Jolla, California
pbaran@
Received April 8, 2010
The field of total synthesis has a rich history and a vibrant future. Landmark advances and
revolutionary strides in the logic of synthesis have put the practicing chemist in the enviable position
of being able to create nearly any molecule with enough time and effort. The stage is now set for
organic chemists to aim for “ideality” in the way molecules are synthesized. This perspective presents
a simple and informative definition of “ideality” and demonstrates its use during the self-evaluation
of several syntheses from our laboratory.
Introduction This prescient statement truly encompassed and epito-
3
mized the “economies” of synthesis design many years
In the 20th century, the art and science of complex natural 4 5 6
before the ideas of atom, step, and redox-economy were
product total synthesis defined the frontiers of organic
1 formally galvanized. Many factors may be
显示全部