QTL作图中零假设检验统计量分布特征及LOD临界值估计方法研究.pdf

作物学报 ACTA AGRONOMICA SINICA 2013, 39(1): 111 /zwxb/ ISSN 0496-3490; CODEN TSHPA9 E-mail: xbzw@ DOI: 10.3724/SP.J.1006.2013.00001 QTL 作图中零假设检验统计量分布特征及LOD 临界值估计方法 孙子淇 李慧慧 张鲁燕 王建康* / / CIMMYT , 100081 : QTL , LOD , , QTL (LRT) LOD , QTL QTL , LRT , QTL ; , LOD , , BC1RIL F2 , BC1 , F2 , , LOD ; QTL , Bonferroni , , , , LOD : QTL ; ; LOD ; ; ; Properties of the Test Statistic under Null Hypothesis and the Calculation of LOD Threshold in Quantitative Trait Loci (QTL) Mapping * SUN Zi-Qi, LI Hui-Hui, ZHANG Lu-Yan, and WANG Jian-Kang Institute of Crop Sciences / National Key Facility for Crop Gene Resources and Genetic Improvement, Chinese Academy of Agricultural Sciences / CIMMYT China Office, Beijing 100081, China Abstract: Selecting an appropriate LOD threshold is of great interest in QTL mapping studies. Many approaches can be consid- ered to calculate the critical value throughout a genome, such as simulation-based method, analytical approximation, and empiri- cal method based on permutation test. Many tests are conducted in QTL mapping, which are not mutually independent because the linkage relationship of adjacent markers on chromosomes. In order to d