血红素氧合酶-1在百草枯中毒鼠肺组织中的表达及三七总皂甙的保护作用.pdf

2012 27 West China Medical Journal Vol.27 No.7 Jul. 2012 1025 -1 (PQ) -1 HO-1 PNS150 SD C 30 PQ PQ 60 PNS 60 PQ PNS PQ 25 mg/kg C PNS 15 min PNS 50 mg/kg 1 /d PQ C 612 h1357 d HO-1 - HO-1 mRNA C HO-1 HO-1 mRNA C PQ PNS HO-1 HO-1 mRNA P 0.05PQ HO-1 HO-1 mRNA 1 d 3 C PNS PQ 6 h12 h1 d 3 d PQ P 0.055 7 P 0.05PQ 612 h13 57 d PNS P 0.05C PQ PNS P 0.001HO-1 PQ PNS PQ -1 A Expression of Heme Oxygenase-1 in the Lung of Paraquat Poisoning Rats and Protective Function of Panax Notoginseng SaponinsHAO Li, QU Yan, WANG Ye, WANG Nan, ZHANG Ming-qian. Yanan Hospital of Kunming City, Kunming, Yunnan 650051, P. R. China Corresponding author: WANG Ye, E-mail: wangye206@126.com Abstract Objective To explore the expression of heme oxygenase-1 (HO-1) in the lung of paraquat poisoning rats and the protection function of panax notoginseng saponins (PNS). MethodsOne hundred and fi fty SD male rats were randomly divided into 3 groups: normal control group (group C, n=30), paraquat poisoning group (group PQ, n=70), and drug intervention group (group PNS, n=70). The groups PQ and PNS rats were given paraquat by gastric perfusion (25 mg/kg); The group C rats were given saline by gastric perfusion. The rats in group PNS were protected by intravenous injection on penis with PNS (50 mg/kg) for 15 min before exposure of paraquat once a day until they were killed. The groups PQ and C rats were given saline. Histological changes of lung tissues under light micr