生物技术药物新剂型研究_国内研究现状及建议.pdf

　Chinese J ournal of New Drugs 2004 ,Vol 13 No 12 中国新药杂志 2004 年第 13 卷第 12 期 　 sessed by elect ron spin resonance , elect ron micro scop y and P harm S ci , 1990 ,79 (8) ∶66767 1 ext ru sion mea surement s [J ] I nt J P harm200 1 , 2 17 ( 1) ∶ [28 ] 　王东凯 ,王翔春 ,张清民,等 影响脂质体在体内稳定性因素 1324 [J ] 沈阳药学院学报 , 1992 ,9 ( 1) ∶7578 [23 ] 　Maghraby GM , Williams A C ,Barry BW Skin delivery of 5 [29 ] 　Dan N Effect of lipo some char ge and P E G polymer layer fluorouracil from ult radefor mable and st andar d lipo somes in t hickness on celllipo some elect ro st atic int eraction s [J ] . B io vit ro [J ] J P harm P harm acol ,200 1 ,53 (8) chi m ica B iop hy s ica A ct a ,2002 , 1564 ∶343348 [24 ] 　Tsuchiha sh M , Harashima H , Kiwada HDevelop ment of a [ 30 ] 　Par k J W , Hong K , Kirpotin DB , et alAntiH ER2 immunoli p haramcokinetic / p har macodynamic ( P K/ PD ) simulation po somes ∶enhanced efficiency at t ribut able to t ar get ed deliv ( ) sy st em for doxorubicin in long circulating lipo somes in mice ery [J ] Cl i n Cancer R es ,2002 ,8 4 u sing p eritoneal P388 [J ] J Cont rol le d R elease , 1999 ,6 1 ( 1 [ 3 1 ] 　Koj i T Charact erization of lipo somes which have fuctional 2) ∶919 polmer chain s on t heir surf aces [J ] M ak u , 1999 ,24 (3) ∶153 [25 ] 　牛国琴 ,陆伟跃 聚乙二醇在脂质体中的作用[J ] 国外医 159 ( ) 药 ·合成药生化药制剂分册 ,2000 ,2 1 3 ∶178181