基于大分子肿瘤靶向.ppt

【般若黑洞】出品 Northwestern Polytechnic University 基于大分子的 药物控释 肿瘤靶向 Polymeric Tumor-Targeting Drug Controlled Release Drug Load 装载 定位 Targeting Drug Release 释放 胶束 Micelles 树枝状聚合物 Dendrimers Liposomes 微脂囊 聚合物-药物 偶联物 Polymer-drug conjugates Drug Load 装载 定位 主动 active 被动 passive Targeting 配合基-受体 Ligand-receptor EPR效应 EPR Effect 叶酸 cRGD 正常组织 癌变部位 Drug Release 释放 pH 温度 降解 磁场 UV 电场 内因 外因 PDEAEMA PNIPAM -s-s- hydrazone bonds 多层 分子设计 Molecular Design 嵌段 分子量 端基 ATRP RAFT 点击化学 超分子 星形 开环 Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy Xiang Lan Wu, Jong Ho Kim Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles as Drug Nanocarriers for Targeted Cancer Therapy Xiaoqiang Yang, Jamison J. Grailer, Srikanth Pilla PEG-SS-PPS: Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery Xiang Lan Wu, Jong Ho Kim Folate-Conjugated Thermoresponsive Block Copolymers: Highly Efficient Conjugation and Solution Self-Assembly Priyadarsi De, Sudershan R. Gondi, and Brent S. Sumerlin Development of multiple-layer polymeric particles for targeted and controlled drug delivery Bhanuprasanth Koppolu, MS, Maham Rahim, O S i O S i O S i S i O S i O S i S i O S i O S i O S i O S i H S i O S i O S i H O S i O S i H S i O S i H N H 2 N H N H 2 N H N H 2 N H N N H 2 grafted PNIPAM Shell β-CD based HBP Core Thermo-Responsive Hyperbranched poly(β-CD)s-g-PNIPAM Thank you! Polymeric Tumor-Targeting Drug Controlled Release /paratop @般若黑洞 * *