助放疗对抗肿瘤免疫影响的研究进展.pdf

中国癌症杂志 2014年第24卷第5期 《 》 392 CHINA ONCOLOGY 2014 Vol.24 No.5 乳腺癌辅助放疗对抗肿瘤免疫 影响的研究进展 王小方 综述　郭小毛 审校 复旦大学附属肿瘤医院放疗科，复旦大学上海医学院肿瘤学系，上海 200032 　　［摘要］　免疫是机体的基本防御屏障，与乳腺癌的发生、发展、治疗及预后密切相关。辅助放疗是乳腺 癌综合治疗的重要组成部分。传统观点认为放疗可直接破坏机体免疫细胞，进而抑制机体免疫的抗肿瘤效果。 而近期研究表明，放疗可刺激免疫系统产生一系列积极反应，有利于肿瘤杀伤过程中抗原的加工、提呈、识别 及肿瘤的最终杀伤。临床方面，放疗联合多种免疫靶向治疗相继进入临床试验阶段。本文将对乳腺癌放疗对抗 肿瘤免疫影响的研究发展及现状进行介绍。 　　 ［关键词］　乳腺癌；放疗；免疫 　　DOI: 10.3969/j.issn.1007-3969.2014.05.012 　　中图分类号：R737.9　　文献标志码：A　　文章编号： 1007-3639(2014)05-0392-05 Progression of adjuvant radiotherapy upon breast cancer immunity WANG Xiao-fang, GUO Xiao- mao (Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China) Correspondence to: GUO Xiao-mao E-mail: guoxm1800@126.com 　　［Abstract ］ Immunity is the basic defense barrier for body, and also closely related to the development, progression, treatment and prognosis of breast cancer. Adjuvant radiotherapy plays an important role in the multidisciplinary treatment of breast cancer. It has long been believed that radiotherapy was immunosuppressive because it could destroy the body’s immune cells directly. While recent studies have shown that radiotherapy can stimulate the host immune system in the antitumor process, including antigen processing, presentation, recognition, and eventually tumor-cell killing. In the clinical aspect, a variety of immune targeted therapies, combined with radiotherapy, have entered clinical trials. The article reviewed research progress and status of the influence of breast cancer adjuvant