运动与心肌细胞凋亡的线粒体机制-体育学刊.pdf

第 17 卷第 3 期 体 育 学 刊 Vol.17 No.3 2010 年 3 月 Journal of Physical Education M a r . 2 0 1 0 运动与心肌细胞凋亡的线粒体机制 21 张琳，邓树勋，郝选明 （华南师范大学体育科学学院，广东 广州 510006 ） 摘 要：综述了线粒体的结构功能及心肌细胞凋亡过程与线粒体的密切关系，探讨其参与运 动诱导心肌细胞凋亡的可能机制。线粒体在心肌细胞凋亡中起关键的作用，细胞凋亡过程中许多 重要事件的发生都与线粒体密切相关，包括线粒体通透转变孔道(mPTP)的开放、线粒体膜电位 (∆Ψ )的丧失、线粒体内外膜间隙促凋亡蛋白的释放、细胞内氧化还原状态的改变、Ca2+超载、Bcl-2 m 家族促进和抑制凋亡蛋白的参与等。 关 键 词：运动医学；线粒体通透转变孔道；线粒体膜间隙；运动；心肌；细胞凋亡；综述 中图分类号：G804.2 文献标识码：A 文章编号：1006-7116(2010)03-0092-07 Mechanisms of mitochondria on cadiocyte apoptosis induced by exercise ZHANG Lin ，DENG Shu-xun ，HAO Xuan-ming （School of Physical Education，South China Normal University，Guangzhou 510006，China ） Abstract: More and more evidence indicated that mitochondria play the key role in cadiocyte apoptosis. Many events happened in apoptotic process have been tightly related to mitochondria, including mitochondrial permeabil- ity transition pore(MPTP) open, the depletion of mitochondrial membrane potential (mitochondrial ∆Ψm), mito- chondrial intermembrane space pro-apoptotic protein release, alteration of redox state, Ca2+ overloading, participa- tion of Bcl-2 family and so on. The mitochondrial structure and function and its tight relation to apoptosis were re- viewed, the possible mechanism of mitochondria on cadiocyte apoptosis induced by exercise were also summarized in the article. Key words: sports medicine；mitochondrial permeability transition pore(mPTP) ；mitochondrial intermembrane space；execise ；c