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儿童特发性关节炎与巨噬细胞活化综合征.pdf

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24 第24卷第2l期2009年11月J铆,c啦砖咖打.VoLNo.21.Nov.2009 ·1631· witIlrimximabin withrheumatoidarthritis MetoA.2005,90(6):3505—3509, targetedtherapy patients a1.Methotrexateinresistant [10]GianniniEH,BrewerEJ,KuzminaN,et ju. [J].NewEnglJMed,2004,350(25):2572—2581. of venilerheumatoidarthritis.ResultsoftheUSA—URSS a1.Clinical toeilizumab double—blind,[17]YokotaS,MiyamaeT,lmngawaT,et study trial.ThePediatric inchildrenwith placebo—controlled RheumatologyCollabotative systemic—onsetjuvenfleidiopathic Rev StudyGroupandtheCooperativeChildren’sStudyGroup[J].Ⅳ凸∥JAlrgyhnmunol,2005,28(3):231—238. It of label trialsin· Med,1992,326:1043—1049. [18]WooP,WilkinsonN,PrieurAM,eta1.Open phase a1.Arandomizedtrialof dosesofMRAinCaucasianchildrenwi£Ilsevero [1】]RupertoN,MurrayKJ,GerloniV,et I锄fnteral e.ascending sys- methotrexateanintermediatedosewitha temic of ofthe of comparing juvenile princ:ipie efficacy hi#erdose,in.chil- idiopathicarthritis:proof drenwith arthritiswhofailedto tostanda
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