代谢综合征患者血清内脏脂肪素与肾功能变化相关性研究.doc

代谢综合征患者血清内脏脂肪素和肾功能变化的相关性研究 【摘要】? 目的 研究代谢综合征(MS)患者血清内脏脂肪素(Visfatin，简称内脂素)和肾功能的变化;并分析它们之间的内在联系。方法 以85例MS患者和88例正常对照为研究对象，MS患者按GFR≥90 ml·min-1·1.73 m-2和GFR90 ml·min-1·1.73 m-2 分为两组，记录并检测临床和生化指标，采用酶联免疫法检测血清内脂素水平，MDRD公式法计算肾小球滤过率(GFR)。结果 MS组和对照组年龄性别匹配。与对照组比较，MS组患者血清内脂素(对数值)和肌酐水平显著升高〔(1.06±0.16)vs(0.98±0.25)ng/ml，P 0.05;(73.20±13.95)vs(63.93±13.78)μmol/L，P0.01〕;GFR水平显著减低〔(90.88±19.91)vs(109.10±32.43)ml·min-1·1.73 m-2，P0.01〕;GFR减低的MS患者血清内脂素水平明显高于GFR正常的MS患者〔(1.11±0.15)vs(1.03±0.16)ng/ml,P0.05〕;直线相关分析GFR与血清内脂素水平呈显著负相关(r=-0.19，P0.05);多元线性回归分析显示血清内脂素水平是GFR的独立危险因素(β=-0.17，P0.01)。结论 血清内脂素水平与MS患者肾功能密切相关，可能是MS患者肾脏病变的重要参与因素。 【关键词】? 代谢综合征; 内脏脂肪素;肾功能;肾小球滤过率 The relationship of serum visfatin and renal function in metabolic syndrome 　　GUO Ling, TAN HongWei, WANG ZhiHao, et al. 　　Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital of Shandong University, Ji′nan 250012, Shandong, China 　　【Abstract】 Objective To investigate the concentration of serum visfatin and renal function, and their relationship in metabolic syndrome(MS). Methods A total of 85 patients with MS and 88 controls were included. The patients were further divided into two groups: 58 cases with Glomerular filtration rate (GFR)≥90 ml·min-1·1.73 m-2 and 27 cases with GFR90 ·min-1·1.73 m-2. Serum visfatin concentration was measured by enzyme immunoassay method. Results Compared with age and sexmatched controls, the concentrations of serum visfatin and creatinine were significantly elevated in MS patients 〔(1.06±0.16) vs (0.98±0.25) ng/ml，P0.05;(73.20±13.95) vs (63.93±13.78) μmol/L，P0.01); the GFR was significantly decreased 〔(90.88±19.91) vs(109.10±32.43) ml·min-1·1.73 m-2(P0.01); and the concentration of serum visfatin was significantly higher in patients with GFR≥90 ml·min-1·1.73 m-2 than that in patients with GFR90 ml·min-1·1.73 m-2 〔(1.11±0.15) vs (1.03±0.16) ng/ml, P0.05). Linear correlation an