Use of ibuprofen in children World Health （使用布洛芬在儿童世界卫生）.PDF

Use of ibuprofen in children, focusing on comparative analgesic and antipyretic efficacy and safety Background nd Currently section 2 of the 2 WHO Model Essential Medicines List for Children (March 2009), contains the following listing for ibuprofen: The note following the inclusion of ibuprofen in this section is explained below: Ibuprofen is also listed in two other parts of the EML for Children, without the additional note. These are in Section 7 and Section 8.4, as shown below: 1 Ibuprofen in children – pain and fever March 2011 Section 8.4: This document presents a review of the evidence for the efficacy and safety of ibuprofen, when used for acute pain and fever in children (aged 12 years and less), for short duration (days, rather than weeks), in particular in comparison with paracetamol. Retrieval of evidence Evidence from systematic reviews and randomised controlled trials was sought from the MEDLINE database, accessed by means of the PubMed portal. The following searches were conducted, using the advanced search option: • (ibuprofen AND pain OR fever AND pediatr*) AND systematic[sb] • (ibuprofen AND pain OR fever AND pediatr*) AND (Therapy/Narrow[filter]) Systematic reviews Three relevant systematic reviews were retrieved. The most recent review retrieved compared the efficacy (in pain and fever) and safety of ibuprofen and paracetamol in both adults and children (Pierce and Voss 2010). This was an update of two previous reviews conducted in 2004 (Goldman, Ko et al. 2004; Perrott, Piira et al. 2004), but extended to include studies in adults. Pierce and Voss (2010) searched MEDLINE up to August 2009 and EMBASE up to January 2008, but restricted both searches to the English language only. They also sought only direct comparisons of ibuprofen and paracetamol, whether pro