TUTORIAL An Introduction to Quadrupole Ion （教程简介四极离子）.pdf

JOURNAL OF MASS SPECTROMETRY, VOL. 32, 351È 369 (1997) SPECIAL FEATURE: TUTORIAL An Introduction to Quadrupole Ion Trap Mass Spectrometry Raymond E. March* Department of Chemistry, Trent University, Peterborough, ON, K9J 7B8, Canada A concise introduction is presented to the theory and application of quadrupole ion trap mass spectrometry. The presentation of the theoretical treatment is based on a demonstration of the equivalence of the force acting on an ion in a quadrupole Ðeld and the force derived from the Mathieu equation; this equivalence permits the application of the solutions of MathieuÏs equation to the conÐnement of gaseous ions. Resonant excitation, collision-induced dissociation, mass spectrometry, tandem mass spectrometry and chemical ionization are discussed in the context of analytical applications. Sample calculations of the trapping parameters q and , the axial secular frequency, mass range, mass range extension and the magnitude of the potential well depth are given. 1997 by John Wiley Sons, Ltd. J. Mass Spectrom. 32, 351È 369 (1997) No. of Figures: 21 No. of Tables: 0 No. of Refs: 21 KEYWORDS: quadrupole ion trap; mass spectrometry; quadrupole ion trap mass spectrometry; quadrupole mass Ðlter INTRODUCTION In addition to the conÐnement of ions, the ion trap functions as a mass spectrometer in that the mass/ charge ratios of the conÐned ion species can be mea- The quadrupole ion trap is an extraordinary device sured. The principal method for measuring the which functions both as