单侧感音神经性耳聋病人听觉传导通路变化的fMRI研究的开题报告.docx

单侧感音神经性耳聋病人听觉传导通路变化的fMRI研究的开题报告

Title:fMRIStudyonChangesinAuditoryConductionPathwayinPatientswithUnilateralSensorineuralHearingLoss

Introduction:

Sensorineuralhearinglossisacommondisorder,whichoftenaffectsoneearmorethantheother.Patientswithunilateralsensorineuralhearinglosshavedifficultyinlocalizingsoundsources,understandingspeechinnoisyenvironments,andmaintainingbalance.Thistypeofhearinglossiscausedbydamagetotheinnerearorauditorynerve,whichresultsinareductioninneuralsignalstothebrain.

Functionalmagneticresonanceimaging(fMRI)isanon-invasivetechniquethatcanprovideinformationonbrainactivationinresponsetodifferentstimuli.PreviousstudieshaveusedfMRItoinvestigatethechangesinauditorypathwayinpatientswithsensorineuralhearingloss.However,themajorityofthesestudieshavefocusedonbilateralhearingloss,andfewhaveinvestigatedthechangesinunilateralhearingloss.

Objective:

ThemainobjectiveofthisstudyistoinvestigatethechangesintheauditoryconductionpathwayinpatientswithunilateralsensorineuralhearinglossusingfMRI.Specifically,wewillexaminetheactivationpatternsintheauditorycortexandotherbrainregionsinresponsetoauditorystimuli.Wewillalsoinvestigatethechangesinthewhitematterstructureoftheauditorypathwayusingdiffusiontensorimaging(DTI).

Methods:

Thestudywillrecruit20patientswithunilateralsensorineuralhearinglossand20healthycontrols.Allparticipantswillundergoacomprehensiveaudiologicalevaluationtoassesstheirhearingsensitivityandspeechrecognitionability.ThefMRIdatawillbeacquiredusinga3TMRIscannerwhiletheparticipantslistentoaseriesofauditorystimuli.TheDTIdatawillalsobeacquiredtoanalyzethewhitematterstructureoftheauditorypathway.ThefMRIandDTIdatawillbeanalyzedusingstandardneuroimagingsoftwaretoidentifythechangesin