the effect of structural design on mechanical properties and cellular response of additive manufactured titanium scaffolds结构设计对机械性能的影响和细胞反应的添加剂生产钛支架.pdf

Materials 2012, 5, 1336-1347; doi:10.3390/ma5081336 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article The Effect of Structural Design on Mechanical Properties and Cellular Response of Additive Manufactured Titanium Scaffolds Jan Wieding *, Anika Jonitz and Rainer Bader Department of Orthopedics, University Medicine Rostock, Doberaner Strasse 142, Rostock 18057, Germany; E-Mails: anika.jonitz@med.uni-rostock.de (A.J.); rainer.bader@med.uni-rostock.de (R.B.) * Author to whom correspondence should be addressed; E-Mail: jan.wieding@med.uni-rostock.de; Tel.: +49-381-494-9338; Fax: +49-381-494-9308. Received: 7 May 2012; in revised form: 29 July 2012 / Accepted: 31 July 2012 / Published: 10 August 2012 Abstract: Restoration of segmental defects in long bones remains a challenging task in orthopedic surgery. Although autologous bone is still the ‘Gold Standard’ because of its high biocompatibility, it has nevertheless been associated with several disadvantages. Consequently, artificial materials, such as calcium phosphate and titanium, have been considered for the treatment of bone defects. In the present study, the mechanical properties of three different scaffold designs were investigated. The scaffolds were made of titanium alloy (Ti6Al4V), fabricated by means of an additive manufacturing process with defined pore geometry and porosities of approximately 70%. Two scaffolds exhibited rectangular struts, orientated